منابع مشابه
Commensal Bacteria Shape Intestinal Immune System Development
M icrobes have a knack for making us sick. Until recently, many of these encounters proved deadly. In Guns, Germs, and Steel, evolutionary biologist Jared Diamond argues that such interactions were a primary force shaping human history. Therefore, it is not surprising that human-microbe interactions often are viewed through the lens of conflict. The proliferation of antibacterial consumer produ...
متن کاملCommensal gut bacteria: mechanisms of immune modulation.
Mucosal immune responses to pathogenic gut bacteria and the mechanisms that govern disease progression and outcome have been researched intensely for decades. More recently, the influence of the resident non-pathogenic or 'commensal' microflora on mucosal immune function and gut health has emerged as an area of scientific and clinical importance. Major differences occur in the mucosal immune re...
متن کاملCommensal Bacteria Modulate Innate Immune Responses of Vaginal Epithelial Cell Multilayer Cultures
The human vaginal microbiome plays a critical but poorly defined role in reproductive health. Vaginal microbiome alterations are associated with increased susceptibility to sexually-transmitted infections (STI) possibly due to related changes in innate defense responses from epithelial cells. Study of the impact of commensal bacteria on the vaginal mucosal surface has been hindered by current v...
متن کاملModulation of host responses by oral commensal bacteria
Immunomodulatory commensal bacteria are proposed to be essential for maintaining healthy tissues, having multiple roles including priming immune responses to ensure rapid and efficient defences against pathogens. The default state of oral tissues, like the gut, is one of inflammation which may be balanced by regulatory mechanisms and the activities of anti-inflammatory resident bacteria that mo...
متن کاملModulation of Systemic Immune Responses through Commensal Gastrointestinal Microbiota
Colonization of the gastrointestinal (GI) tract is initiated during birth and continually seeded from the individual's environment. Gastrointestinal microorganisms play a central role in developing and modulating host immune responses and have been the subject of investigation over the last decades. Animal studies have demonstrated the impact of GI tract microbiota on local gastrointestinal imm...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2015
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3906